In korea, cervical carcinoma is the most common malignant tumor of the women. But the pathophysiology and prognosis of the cervical cancer is not well known. Several different classifications have been proposed through the years. But the
international
classification that has been adopted by FIGO is now widely used for the determination of therapeutic modalities and prognosis. And it is the most helpful prognostic factor in predicting survival.
We can not know the biological characteristics of cervical cancer precisely by the histological findings alone. So many investigators have been studying to find the other prognostic factors. Recently according to the development of molecular
biology,
the DNA patterns of many malignant tumors are well known. But in cervical carcinoma, the relationship between the biological characteristics and DNA patterns of cervical cells are not investigated fully. In this study, we tried to find out the
relationship between DNA patterns by flowcytometry and the prognosis of cervical carcinoma. The subjects were 56 patients who were admitted to Seoul National University Hospital from January 1985 to December 1986 under the diagnosis of cervical
carcinoma Samples were obtained from the subjects prior to radiotherapy or chemotherapy and follow up study were carried out for a period of 5 years. And the author examined the DNA patterns of the tissue in the paraffin embedded tissues after
surgery,
and observed the relations among the flowcytometric DNA patterns, clinical stage, age, histopathological findings, primary tumor size, cervical invasion depth and lymph node metastasis.
@ES The results were as follows;
@EN 1. The S-phase and relative DNA index increased in stage Ia, Ib, IIa, IIb compared to those of stage 0(p<0.5).
2. The incidence of aneuploidy tumor was significantly increased with the stage and age of patients(p=0.04, p=0.021).
3. There were significant difference between the sq? ous cell carcinoma and adenocarcinoma but no relationship between the groups with keratinizing cell type and non keratinizing type.
4. There were significant difference with the metastasis to lymph node (p=0.034).
5. The incidence of aneuploidy group was significantly increased in recurrent group (p=0.006).
6. In the aneuploidy group, 5-year disease free survival rate was lower than that of diploidy group(0.006).
From the above results, it is considered that the effect of treatment in cervical carcinoma and its prognosis can be more precisely predicted by DNA patterns by flowcytometry with other clinicopathological prognostic factors.
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